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1 article(s) from Wynne, Graham M

Anthelmintic drug discovery: target identification, screening methods and the role of open science

Frederick A. Partridge,
Ruth Forman,
Carole J. R. Bataille,
Graham M. Wynne,
Marina Nick,
Angela J. Russell,
Kathryn J. Else and
David B. Sattelle

Beilstein J. Org. Chem. 2020, 16, 1203–1224, doi:10.3762/bjoc.16.105

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Figure 1: Structures of some current front-line anthelmintics discussed in this review. *Denotes the stereoge...

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Figure 2: Structures of new anthelmintics drugs developed through repurposing, and new drugs or drug candidat...

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Figure 3: Compounds with anthelmintic activity identified by a combination of screening against Ancylostoma c...

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Figure 4: Inhibitors of S. mansoni thioredoxin glutathione reductase with anthelmintic activity [140].

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Figure 5: Active compounds from anthelmintic screens using the MMV Pathogen Box. NTS: newly transformed schis...

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Figure 6: Two resolution approaches to enantiopure PZQ (R)-5 discovered through A) open science and B) contra...

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Review

Published 02 Jun 2020

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